Biopharmaceutical companies today are challenged to develop high-producing cell lines as quickly as possible. New strategies and optimal cell environments are emerging as a result of developments in cell engineering, better culture conditions, and improved culture analyses.
Recent developments in genetic engineering, digitalization, automation, proteomics, metabolomics, and transcriptomics, as well as systems and synthetic biology, have deepened our understanding of cell culture and cell line processes and sped up the development of cell lines for the manufacture of high-quality biologics.
As Cell line development (CLD) and the development of the first clinical batch is on the critical path for advancing a novel therapeutic to a clinical trial, companies are looking to do anything they can to make the development process faster.
Cell culture processes are a vital part of manufacturing, yet the bioprocessing industry still needs optimized process development approaches.
To address these issues, scientists are developing cutting-edge methods and apparatus, particularly for complex biologics like bispecific antibodies (BsAbs) and difficult-to-express (DTE) proteins. A digital environment and a "laboratory of the future" consisting of a device layer, workflow and data layer, system layer, integration layer, and an analysis and visual layer are being created by biopharmaceutical developers. The goal is to have a fully automated CLD workstream.
There are various obstacles to overcome while creating a commercial cell culture process, including enhancing cell culture conditions to preserve product quality and boost process efficiency.
Companies are looking to more advanced technologies and better process design as we move into the next decade. Examples include systems and transcriptomics approach to cell engineering and glycosylation, more stable expressions from CHO cells, as well as advanced processing and manufacturing platforms for emerging biologics.
Join us on 28th - 29th March, 2023 for the International Bioprocessing and Biologics Forum, in Berlin, Germany so you don't feel left out in the industry!
To register or learn more about the Forum please check here: https://bit.ly/3zxguXW
For more information and group participation, contact us: [email protected]
