One of the most significant advancements in biomanufacturing is the creation of single-use technologies (SUTs). For a very long time, pharmacological compounds have been stored and cooled in large stainless steel containers. However, a change in favour of SUT has improved production flexibility and agility. The development of single-use systems has also created a strong platform for enhancing the production of a variety of biopharmaceuticals, including mRNA, allogeneic cell therapies, and viral-vectored gene therapies. Single-use equipment makes sense, especially for newer modalities. Such therapies require prompt filling, freezing, and shipping from manufacturers. SUTs make it possible to produce in several modes, increase throughput, and speed up changeover processes. Disposable bioprocess systems enable businesses to work more flexibly by dividing up standard batch sizes.
Single-use technology (SUT) describes goods or services that are designed to be used just once. These items are typically disposable after use and made of plastic (polyamide, polycarbonate, polyethylene, polyethersulfone, polypropylene, polytetrafl urethylane, polyvinyl chloride, cellulose acetate, ethylene vinyl acetate).
SUT has developed into a robust technology, and multiple global pharmaceutical and biotech companies have accumulated extensive experience in both API manufacture and the fill-finish phase for drug substance or drug products.
Single-use technology serves as the best answer for any biopharmaceutical company, regardless of the problems with flexibility, speed to market, product quality, or operator safety. The most frequently mentioned benefits of SUT are investment and variable cost savings, although they only make up a small part of a crucial strategic choice in production technology. Single-use technology nowadays involves a wide range of front-end factors, including waste management, process compatibility, leachables/extractables, film selection, and backup suppliers. Additionally, the quality assurance system needs to be expanded to include both production technology and raw materials.
It is anticipated that in the near future, SUT will be used beyond the biopharmaceutical field (food, cosmetics, etc.) and animal cell culture (microorganisms, plant cell and tissue cultures, algae. Join us on 28th - 29th March, 2023 for the International Bioprocessing and Biologics Forum, in Berlin, Germany to learn about biomanufacturing strategies to meet the needs of multiple modalities in biologics.
To register or learn more about the Forum please check here: https://bit.ly/3zxguXW
For more information and group participation, contact us: [email protected]
